Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-11-11
pubmed:abstractText
The cross-talk between Wnt signaling and the Akt pathway in prostate cancer (Pca) is still unclear. In the present study, we found that WIF-1 downregulates the Akt pathway and also enhances chemosensitivity in PTEN-null Pca cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase, http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/WIF1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0270-4137
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-8
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:15389810-Adaptor Proteins, Signal Transducing, pubmed-meshheading:15389810-Antineoplastic Agents, Phytogenic, pubmed-meshheading:15389810-Apoptosis, pubmed-meshheading:15389810-Carrier Proteins, pubmed-meshheading:15389810-Cell Line, Tumor, pubmed-meshheading:15389810-Cytoskeletal Proteins, pubmed-meshheading:15389810-Down-Regulation, pubmed-meshheading:15389810-Drug Resistance, Neoplasm, pubmed-meshheading:15389810-Gene Expression, pubmed-meshheading:15389810-Glycogen Synthase Kinase 3, pubmed-meshheading:15389810-Humans, pubmed-meshheading:15389810-Male, pubmed-meshheading:15389810-Mutation, pubmed-meshheading:15389810-PTEN Phosphohydrolase, pubmed-meshheading:15389810-Paclitaxel, pubmed-meshheading:15389810-Phosphoric Monoester Hydrolases, pubmed-meshheading:15389810-Prostatic Neoplasms, pubmed-meshheading:15389810-Protein-Serine-Threonine Kinases, pubmed-meshheading:15389810-Proto-Oncogene Proteins, pubmed-meshheading:15389810-Proto-Oncogene Proteins c-akt, pubmed-meshheading:15389810-Repressor Proteins, pubmed-meshheading:15389810-Signal Transduction, pubmed-meshheading:15389810-Trans-Activators, pubmed-meshheading:15389810-Transfection, pubmed-meshheading:15389810-Tumor Suppressor Proteins, pubmed-meshheading:15389810-beta Catenin
pubmed:year
2005
pubmed:articleTitle
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.
pubmed:affiliation
Department of Urology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ohigashi@sc.itc.keio.ac.jp
pubmed:publicationType
Journal Article