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15389810
Source:
http://linkedlifedata.com/resource/pubmed/id/15389810
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0021467
,
umls-concept:C0021469
,
umls-concept:C0037083
,
umls-concept:C0205263
,
umls-concept:C0334227
,
umls-concept:C0376358
,
umls-concept:C0441655
,
umls-concept:C1710082
,
umls-concept:C2347610
pubmed:issue
1
pubmed:dateCreated
2004-11-11
pubmed:abstractText
The cross-talk between Wnt signaling and the Akt pathway in prostate cancer (Pca) is still unclear. In the present study, we found that WIF-1 downregulates the Akt pathway and also enhances chemosensitivity in PTEN-null Pca cells.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/8101368
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing
,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic
,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3
,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase
,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel
,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases
,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases
,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt
,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/WIF1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0270-4137
pubmed:author
pubmed-author:MarumoKK
,
pubmed-author:MizunoRR
,
pubmed-author:MuraiMM
,
pubmed-author:NakashimaJJ
,
pubmed-author:OhigashiTT
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-8
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:15389810-Adaptor Proteins, Signal Transducing
,
pubmed-meshheading:15389810-Antineoplastic Agents, Phytogenic
,
pubmed-meshheading:15389810-Apoptosis
,
pubmed-meshheading:15389810-Carrier Proteins
,
pubmed-meshheading:15389810-Cell Line, Tumor
,
pubmed-meshheading:15389810-Cytoskeletal Proteins
,
pubmed-meshheading:15389810-Down-Regulation
,
pubmed-meshheading:15389810-Drug Resistance, Neoplasm
,
pubmed-meshheading:15389810-Gene Expression
,
pubmed-meshheading:15389810-Glycogen Synthase Kinase 3
,
pubmed-meshheading:15389810-Humans
,
pubmed-meshheading:15389810-Male
,
pubmed-meshheading:15389810-Mutation
,
pubmed-meshheading:15389810-PTEN Phosphohydrolase
,
pubmed-meshheading:15389810-Paclitaxel
,
pubmed-meshheading:15389810-Phosphoric Monoester Hydrolases
,
pubmed-meshheading:15389810-Prostatic Neoplasms
,
pubmed-meshheading:15389810-Protein-Serine-Threonine Kinases
,
pubmed-meshheading:15389810-Proto-Oncogene Proteins
,
pubmed-meshheading:15389810-Proto-Oncogene Proteins c-akt
,
pubmed-meshheading:15389810-Repressor Proteins
,
pubmed-meshheading:15389810-Signal Transduction
,
pubmed-meshheading:15389810-Trans-Activators
,
pubmed-meshheading:15389810-Transfection
,
pubmed-meshheading:15389810-Tumor Suppressor Proteins
,
pubmed-meshheading:15389810-beta Catenin
pubmed:year
2005
pubmed:articleTitle
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.
pubmed:affiliation
Department of Urology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ohigashi@sc.itc.keio.ac.jp
pubmed:publicationType
Journal Article