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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0023516,
umls-concept:C0031621,
umls-concept:C0031689,
umls-concept:C0296250,
umls-concept:C1334043,
umls-concept:C1334333,
umls-concept:C1418576,
umls-concept:C1418577,
umls-concept:C1423080,
umls-concept:C1423613,
umls-concept:C1705639,
umls-concept:C1711351,
umls-concept:C2697616
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pubmed:issue |
1-3
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pubmed:dateCreated |
2004-9-24
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pubmed:abstractText |
To investigate additional functions of the T cell adaptor, Src homology 2 (SH2) domain-containing leukocyte protein of 76 kD (SLP-76), we performed a yeast two-hybrid assay using the N-terminal region of SLP-76 fused with the kinase domain of Syk. By screening a human leukemia cDNA library, we identified the p85 subunit of phosphoinositide 3-kinase (PI3K) as one of the interacting molecules. Unlike the SH2 domain of Vav or Nck, tyrosine phosphorylation of SLP-76 at position 113 or 128 was sufficient for it to associate with the N-terminal SH2 of p85. Collectively, these data suggest that SLP-76 may play a role in PI3K signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nck protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLP-76 signal Transducing adaptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase,
http://linkedlifedata.com/resource/pubmed/chemical/emt protein-tyrosine kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
575
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-40
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:15388330-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15388330-Cell Line,
pubmed-meshheading:15388330-Enzyme Precursors,
pubmed-meshheading:15388330-Humans,
pubmed-meshheading:15388330-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15388330-MAP Kinase Signaling System,
pubmed-meshheading:15388330-Oncogene Proteins,
pubmed-meshheading:15388330-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15388330-Phosphoproteins,
pubmed-meshheading:15388330-Phosphorylation,
pubmed-meshheading:15388330-Protein Binding,
pubmed-meshheading:15388330-Protein Structure, Tertiary,
pubmed-meshheading:15388330-Protein-Tyrosine Kinases,
pubmed-meshheading:15388330-Recombinant Fusion Proteins,
pubmed-meshheading:15388330-Two-Hybrid System Techniques
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pubmed:year |
2004
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pubmed:articleTitle |
Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.
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pubmed:affiliation |
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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