Linked Life Data

1538751

Source:http://linkedlifedata.com/resource/pubmed/id/1538751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6361
pubmed:dateCreated
1992-3-27
pubmed:abstractText
Presentation of cytoplasmic antigens to class I-restricted cytotoxic T cells implied the existence of a specialized peptide transporter. For most class I heavy chains, association with peptides of the appropriate length is required for stable assembly with beta 2-microglobulin. Mutant cells RMA-S and .174/T2 neither assemble stable class I molecules nor present intracellular antigens, and we have suggested that they have lost a function required for the transport of short peptides from the cytosol to the endoplasmic reticulum. The genetic defect in .174 has been localized to a large deletion in the class II region of the major histocompatibility complex, within which two genes (RING4 and RING11) have been identified that code for 'ABC' (ATP-binding cassette) transporters. We report here that the protein products of these two genes assemble to form a complex. Defects in either protein result in the formation of unstable class I molecules and loss of presentation of intracellular antigens. The molecular defect in a new mutant, BM36.1, is shown to be in the ATP-binding domain of the RING11/PSF2 protein. This is in contrast to the mutant .134, which lacks the RING4/PSF1 protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
355
pubmed:geneSymbol
RING11, RING4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
641-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1538751-ATP-Binding Cassette Transporters, pubmed-meshheading:1538751-Amino Acid Sequence, pubmed-meshheading:1538751-Base Sequence, pubmed-meshheading:1538751-Blotting, Southern, pubmed-meshheading:1538751-Carrier Proteins, pubmed-meshheading:1538751-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:1538751-Gene Expression, pubmed-meshheading:1538751-Genotype, pubmed-meshheading:1538751-Histocompatibility Antigens Class I, pubmed-meshheading:1538751-Humans, pubmed-meshheading:1538751-Major Histocompatibility Complex, pubmed-meshheading:1538751-Membrane Proteins, pubmed-meshheading:1538751-Molecular Sequence Data, pubmed-meshheading:1538751-Mutation, pubmed-meshheading:1538751-Precipitin Tests, pubmed-meshheading:1538751-Protein Biosynthesis, pubmed-meshheading:1538751-Transformation, Genetic
pubmed:year
1992
pubmed:articleTitle
Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.
pubmed:affiliation
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't