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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-10-8
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pubmed:abstractText |
Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1471-2156
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pubmed:author |
pubmed-author:AhsanHabibulH,
pubmed-author:BaddiLisaL,
pubmed-author:EllisNathanN,
pubmed-author:FengZ PZP,
pubmed-author:KaklamaniVirginiaV,
pubmed-author:LiuJunjianJ,
pubmed-author:OddouxCaroleC,
pubmed-author:OffitKennethK,
pubmed-author:OstrerHarryH,
pubmed-author:PascheBorisB,
pubmed-author:RosmanDianaD
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15385056-Activin Receptors, Type I,
pubmed-meshheading:15385056-Adult,
pubmed-meshheading:15385056-Aged,
pubmed-meshheading:15385056-Aged, 80 and over,
pubmed-meshheading:15385056-Alleles,
pubmed-meshheading:15385056-Genetic Predisposition to Disease,
pubmed-meshheading:15385056-Humans,
pubmed-meshheading:15385056-Male,
pubmed-meshheading:15385056-Middle Aged,
pubmed-meshheading:15385056-Prostatic Neoplasms,
pubmed-meshheading:15385056-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15385056-Receptors, Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
No major association between TGFBR1*6A and prostate cancer.
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pubmed:affiliation |
Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. virginia.kaklamani@prodigy.net
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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