Linked Life Data

15384983

Source:http://linkedlifedata.com/resource/pubmed/id/15384983

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15384983rdf:typepubmed:Citationlld:pubmed
pubmed-article:15384983lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0225336lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0030190lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C1327287lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:15384983lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:15384983pubmed:issue1lld:pubmed
pubmed-article:15384983pubmed:dateCreated2004-9-23lld:pubmed
pubmed-article:15384983pubmed:abstractTextModified lipoproteins have been suggested to modulate endothelial expression of plasminogen activator inhibitor-1 (PAI-1). As oxidized high-density lipoprotein (Ox-HDL) has been found in atheromatous plaques and receptors for modified HDL are present on endothelial cells, we investigated the role of Ox-HDL3 on the expression of PAI-1. Ox-HDL3 but not native HDL3, increased PAI-1 mRNA expression in endothelial cells. Furthermore, PAI-1 antigen expression and activity increased in the supernatant of cells incubated with Ox-HDL3. The intracellular pathways involved in this effect were investigated. Ox-HDL3 activated both extracellular signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK). Moreover, incubation with specific inhibitors of these kinases showed that p38MAPK was mainly involved in the Ox-HDL3-dependent PAI-1 induction. Transient transfection experiments suggested that none of the response elements in the proximal promoter (-804 to 17) were involved in Ox-HDL3-mediated PAI-1 expression. mRNA stability experiments showed that Ox-HDL3 increased the PAI-1 mRNA half-life. In summary, Ox-HDL3 induced PAI-1 mRNA expression and antigen release through a molecular mechanism involving MAPK activation and mRNA stabilization. Thus, oxidative modification converts HDL to a prothrombotic lipoprotein species.lld:pubmed
pubmed-article:15384983pubmed:languageenglld:pubmed
pubmed-article:15384983pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:citationSubsetIMlld:pubmed
pubmed-article:15384983pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15384983pubmed:statusMEDLINElld:pubmed
pubmed-article:15384983pubmed:monthOctlld:pubmed
pubmed-article:15384983pubmed:issn0007-1048lld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:HamstenAnders...lld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:TremoliElenaElld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:PirilloAngela...lld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:ErikssonPerPlld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:CatapanoAlber...lld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:BanfiCristina...lld:pubmed
pubmed-article:15384983pubmed:authorpubmed-author:NorataGiusepp...lld:pubmed
pubmed-article:15384983pubmed:copyrightInfoCopyright 2004 Blackwell Publishing Ltdlld:pubmed
pubmed-article:15384983pubmed:issnTypePrintlld:pubmed
pubmed-article:15384983pubmed:volume127lld:pubmed
pubmed-article:15384983pubmed:ownerNLMlld:pubmed
pubmed-article:15384983pubmed:authorsCompleteYlld:pubmed
pubmed-article:15384983pubmed:pagination97-104lld:pubmed
pubmed-article:15384983pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:meshHeadingpubmed-meshheading:15384983...lld:pubmed
pubmed-article:15384983pubmed:year2004lld:pubmed
pubmed-article:15384983pubmed:articleTitleOxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization.lld:pubmed
pubmed-article:15384983pubmed:affiliationDepartment of Pharmacological Sciences, University of Milan, Milan, Italy. danilo.norata@unimi.itlld:pubmed
pubmed-article:15384983pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15384983pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15384983lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15384983lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15384983lld:pubmed