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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
40
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pubmed:dateCreated |
2004-10-7
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pubmed:abstractText |
We compared monocyte-derived dendritic cells and transforming growth factor-beta1-induced Langerhans-like cells (LCs) for their capacity to cross-present exogenous NY-ESO-1 protein/antibody immune complexes to an NY-ESO-1-specific CD8+ T cell clone. In contrast to dendritic cells, LCs were not able to cross-present NY-ESO-1 to the T cell clone constitutively but did so after treatment with IFN-gamma. Remarkably, this IFN-gamma-inducible characteristic was due neither to enhanced antigen uptake nor to facilitated antigen processing in LCs. Rather, IFN-gamma acted at least in part by potentiating the maturation of otherwise refractory LCs, enabling in turn exogenous antigen to reach the processing machinery. This model of conditional cross-presentation establishes an original level of action for IFN-gamma as an effective immune modulator and supports the use of IFN-gamma in protein vaccination strategies targeting LCs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10201996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10559964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10684854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10781081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10783867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10969798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-10987311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11005863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11259659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11509172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11726219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11781374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-11861614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12000969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12093890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12138174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12747757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12835477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12853579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-12933572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-14508489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-14508490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-6435701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-7252134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-7629501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-7836932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-8102389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9022030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9050879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9269778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9432985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9500798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9547346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15383663-9892619
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CTAG1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A*02:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14467-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15383663-Amino Acid Sequence,
pubmed-meshheading:15383663-Antigen Presentation,
pubmed-meshheading:15383663-Antigens, Neoplasm,
pubmed-meshheading:15383663-Cell Differentiation,
pubmed-meshheading:15383663-Cell Line,
pubmed-meshheading:15383663-Dendritic Cells,
pubmed-meshheading:15383663-HLA-A Antigens,
pubmed-meshheading:15383663-HLA-A2 Antigen,
pubmed-meshheading:15383663-Humans,
pubmed-meshheading:15383663-Interferon-gamma,
pubmed-meshheading:15383663-Langerhans Cells,
pubmed-meshheading:15383663-Membrane Proteins,
pubmed-meshheading:15383663-Molecular Sequence Data,
pubmed-meshheading:15383663-Phenotype,
pubmed-meshheading:15383663-Recombinant Proteins,
pubmed-meshheading:15383663-Signal Transduction,
pubmed-meshheading:15383663-Transforming Growth Factor beta,
pubmed-meshheading:15383663-Transforming Growth Factor beta1
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pubmed:year |
2004
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pubmed:articleTitle |
IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
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