Linked Life Data

15382646

Source:http://linkedlifedata.com/resource/pubmed/id/15382646

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-9-22
pubmed:abstractText
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their structure. We now report that ordered surface arrays (orthogonal or hexagonal) of nanopits in polycaprolactone or polymethylmethacrylate have marked effects in reducing cell adhesion compared with less regular arrays or planar surfaces. The pits had diameters of 35, 75, and 120 nm, respectively, with pitch between the pits of 100, 200, and 300 nm, respectively. The cells appear to be able to distinguish between different symmetries of array. We suggest that interfacial forces may be organized by the nanostructures to affect the cells in the same way as they affect liquid crystal orientations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1536-1241
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-5
pubmed:dateRevised
2008-8-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Cells react to nanoscale order and symmetry in their surroundings.
pubmed:affiliation
Centre for Cell Engineering, University of Glasgow, Glasgow G12 8QQ, UK. a.curtis@bio.gla.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't