Linked Life Data

15382054

Source:http://linkedlifedata.com/resource/pubmed/id/15382054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-9-21
pubmed:abstractText
Angiogenesis is critical to the growth and metastasis of solid tumors, and acquired drug resistance is one of the major hindrances to chemotherapy. Thus, we sought a rational strategy using the combination of antiangiogenic biotherapy and chemotherapy for cancer therapy. We explored the efficacy of a strategy combining low-dose cisplatin and a recombinant xenogeneic endoglin as a protein vaccine, which we previously demonstrated to have effective antiangiogenic effects in several mouse models. We found that both low-dosage cisplatin and xenogeneic endoglin vaccine individually resulted in effective suppression of tumor growth in 2 tumor models via inhibition of tumor angiogenesis. Remarkably, the combination therapy resulted in not only significant antiangiogenic effects but also additional promotion of tumor cell apoptosis and inhibition of tumor cell proliferation, without any ensuing increase in host toxicity during the course of treatment, which lasted for 6 months. In addition, the combination demonstrated a synergistic relationship, which was shown in all of the synergistic indexes, i.e., tumor volume, angiogenesis, apoptosis and proliferation. Both antibodies and antibody-producing B cells against mouse self-endoglin were observed in all mice immunized by the xenogeneic endoglin vaccine (alone and combination), which suggested that low-dose cisplatin did not suppress the host immune response but potentiated the antitumor activity of the xenogeneic endoglin vaccine. These observations may provide the basis for an effective alternative strategy for cancer therapy in the near future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
701-6
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed-meshheading:15382054-Animals, pubmed-meshheading:15382054-Antigens, CD, pubmed-meshheading:15382054-Antigens, Heterophile, pubmed-meshheading:15382054-Antineoplastic Agents, pubmed-meshheading:15382054-Apoptosis, pubmed-meshheading:15382054-Cancer Vaccines, pubmed-meshheading:15382054-Carcinoma, Lewis Lung, pubmed-meshheading:15382054-Cisplatin, pubmed-meshheading:15382054-Colonic Neoplasms, pubmed-meshheading:15382054-Combined Modality Therapy, pubmed-meshheading:15382054-Disease Models, Animal, pubmed-meshheading:15382054-Dose-Response Relationship, Drug, pubmed-meshheading:15382054-Drug Interactions, pubmed-meshheading:15382054-Female, pubmed-meshheading:15382054-Humans, pubmed-meshheading:15382054-Mice, pubmed-meshheading:15382054-Neovascularization, Pathologic, pubmed-meshheading:15382054-Receptors, Cell Surface, pubmed-meshheading:15382054-Transplantation, Heterologous, pubmed-meshheading:15382054-Vascular Cell Adhesion Molecule-1
pubmed:year
2004
pubmed:articleTitle
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities.
pubmed:affiliation
Key Laboratory of Biotherapy of Human Diseases of the Ministry of Education and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't