| pubmed-article:15380867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0026649 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C1522391 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15380867 | lifeskim:mentions | umls-concept:C0857021 | lld:lifeskim |
| pubmed-article:15380867 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15380867 | pubmed:dateCreated | 2004-9-21 | lld:pubmed |
| pubmed-article:15380867 | pubmed:abstractText | The effects induced by serotonergic (5-HT) agonists of the 5-HT1 and 5-HT2 subclasses were examined on hindlimb movement generation in adult mice completely spinal cord transected at the low thoracic level. One week postspinalization, intraperitoneal injection (0.5-10 mg/kg) of meta-chlorophenylpiperazine (m-CPP; 5-HT(2B/2C) agonist) or trifluoromethylpiperazine (TFMPP; 5-HT(1B) agonist) failed to induce locomotor-like movements. However, dose-dependent nonlocomotor movements were induced in air-stepping condition or on a motor-driven treadmill. In contrast, hindlimb locomotor-like movements were found after the injection of quipazine (5-HT(2A/2C) agonist; 1-2 mg/kg). Combined with L-DOPA (50 mg/kg, i.p.), low doses of quipazine but not of m-CPP and TFMPP produced locomotor-like and nonlocomotor movements in air-stepping condition or on the treadmill. Subsequent administration of m-CPP or TFMPP significantly reduced and often completely abolished the hindlimb movements induced by quipazine and L-DOPA. Altogether, these results demonstrate that 5-HT(2A/2C) receptor agonists promote locomotion while 5-HT(1B) and 5-HT(2B/2C) receptor agonists interfere with locomotor genesis in the hindlimbs of complete paraplegic mice. These results suggest that only subsets of spinal 5-HT receptors are specific to locomotor rhythmogenesis and should be activated to successfully induce stepping movements after spinal cord injury. | lld:pubmed |
| pubmed-article:15380867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15380867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15380867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15380867 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15380867 | pubmed:issn | 0278-5846 | lld:pubmed |
| pubmed-article:15380867 | pubmed:author | pubmed-author:GuertinPierre... | lld:pubmed |
| pubmed-article:15380867 | pubmed:author | pubmed-author:LandryEric... | lld:pubmed |
| pubmed-article:15380867 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15380867 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:15380867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15380867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15380867 | pubmed:pagination | 1053-60 | lld:pubmed |
| pubmed-article:15380867 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:meshHeading | pubmed-meshheading:15380867... | lld:pubmed |
| pubmed-article:15380867 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15380867 | pubmed:articleTitle | Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice. | lld:pubmed |
| pubmed-article:15380867 | pubmed:affiliation | Department of Anatomy and Physiology, Laval University, Research Centre of the Laval University Research Hospital (CRCHUL-CHUQ), 2705 Bld Laurier, RC-9800, Quebec City, Quebec, G1V4G2, Canada. | lld:pubmed |
| pubmed-article:15380867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15380867 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15380867 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15380867 | lld:pubmed |
