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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-9-21
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pubmed:abstractText |
The effects induced by serotonergic (5-HT) agonists of the 5-HT1 and 5-HT2 subclasses were examined on hindlimb movement generation in adult mice completely spinal cord transected at the low thoracic level. One week postspinalization, intraperitoneal injection (0.5-10 mg/kg) of meta-chlorophenylpiperazine (m-CPP; 5-HT(2B/2C) agonist) or trifluoromethylpiperazine (TFMPP; 5-HT(1B) agonist) failed to induce locomotor-like movements. However, dose-dependent nonlocomotor movements were induced in air-stepping condition or on a motor-driven treadmill. In contrast, hindlimb locomotor-like movements were found after the injection of quipazine (5-HT(2A/2C) agonist; 1-2 mg/kg). Combined with L-DOPA (50 mg/kg, i.p.), low doses of quipazine but not of m-CPP and TFMPP produced locomotor-like and nonlocomotor movements in air-stepping condition or on the treadmill. Subsequent administration of m-CPP or TFMPP significantly reduced and often completely abolished the hindlimb movements induced by quipazine and L-DOPA. Altogether, these results demonstrate that 5-HT(2A/2C) receptor agonists promote locomotion while 5-HT(1B) and 5-HT(2B/2C) receptor agonists interfere with locomotor genesis in the hindlimbs of complete paraplegic mice. These results suggest that only subsets of spinal 5-HT receptors are specific to locomotor rhythmogenesis and should be activated to successfully induce stepping movements after spinal cord injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(3-chlorophenyl)piperazine,
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Quipazine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT2,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/trifluoromethylpyridine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0278-5846
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1053-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15380867-Analysis of Variance,
pubmed-meshheading:15380867-Animals,
pubmed-meshheading:15380867-Antiparkinson Agents,
pubmed-meshheading:15380867-Disease Models, Animal,
pubmed-meshheading:15380867-Drug Interactions,
pubmed-meshheading:15380867-Exercise Test,
pubmed-meshheading:15380867-Hindlimb,
pubmed-meshheading:15380867-Levodopa,
pubmed-meshheading:15380867-Locomotion,
pubmed-meshheading:15380867-Male,
pubmed-meshheading:15380867-Mice,
pubmed-meshheading:15380867-Movement,
pubmed-meshheading:15380867-Paraplegia,
pubmed-meshheading:15380867-Piperazines,
pubmed-meshheading:15380867-Pyridines,
pubmed-meshheading:15380867-Quipazine,
pubmed-meshheading:15380867-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:15380867-Receptors, Serotonin, 5-HT2,
pubmed-meshheading:15380867-Serotonin 5-HT1 Receptor Agonists,
pubmed-meshheading:15380867-Serotonin 5-HT2 Receptor Agonists,
pubmed-meshheading:15380867-Serotonin Receptor Agonists,
pubmed-meshheading:15380867-Spinal Cord Injuries
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pubmed:year |
2004
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pubmed:articleTitle |
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.
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pubmed:affiliation |
Department of Anatomy and Physiology, Laval University, Research Centre of the Laval University Research Hospital (CRCHUL-CHUQ), 2705 Bld Laurier, RC-9800, Quebec City, Quebec, G1V4G2, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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