|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2004-9-21
|
|
pubmed:abstractText |
Heart failure is a major and escalating public health problem. Recent studies have demonstrated that statins prevented chronic heart failure (CHF) in animal studies. However, it is unknown whether statins therapy initiated after left ventricular (LV) hypertrophy is evident can still effectively prevent CHF. This study tested the hypothesis that statins can prevent the transition of hypertrophy to heart failure.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0022-2828
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
889-96
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15380679-Animals,
pubmed-meshheading:15380679-Aortic Coarctation,
pubmed-meshheading:15380679-Aortic Valve Stenosis,
pubmed-meshheading:15380679-Apoptosis,
pubmed-meshheading:15380679-Atrial Natriuretic Factor,
pubmed-meshheading:15380679-Cardiac Output, Low,
pubmed-meshheading:15380679-Caspase 3,
pubmed-meshheading:15380679-Caspases,
pubmed-meshheading:15380679-Chronic Disease,
pubmed-meshheading:15380679-Heart Ventricles,
pubmed-meshheading:15380679-Hydrogen Peroxide,
pubmed-meshheading:15380679-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15380679-Hypertrophy, Left Ventricular,
pubmed-meshheading:15380679-Male,
pubmed-meshheading:15380679-Myocytes, Cardiac,
pubmed-meshheading:15380679-Oxidative Stress,
pubmed-meshheading:15380679-RNA, Messenger,
pubmed-meshheading:15380679-Rats,
pubmed-meshheading:15380679-Simvastatin,
pubmed-meshheading:15380679-Superoxides
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis.
|
|
pubmed:affiliation |
Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
