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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2004-9-21
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pubmed:abstractText |
The discovery of a series of quinazolinone-based fungal efflux pump inhibitors by high-throughput screening for potentiation of fluconazole in C. albicans is described. Attempts to improve the aqueous solubility of screening hits led to the discovery of an analog with greatly improved physical properties and activity against clinically-relevant Candida spp.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChoAesopA,
pubmed-author:DudleyMichael NMN,
pubmed-author:GlinkaTomasz WTW,
pubmed-author:IqbalNadeemN,
pubmed-author:LemoineRémy CRC,
pubmed-author:LolansKarenK,
pubmed-author:LomovskayaOlgaO,
pubmed-author:MadsenDeidreD,
pubmed-author:SinghRajeshwarR,
pubmed-author:WatkinsWilliam JWJ,
pubmed-author:WeiKunK,
pubmed-author:YangJessieJ
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5127-31
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pubmed:dateRevised |
2009-7-23
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pubmed:meshHeading |
pubmed-meshheading:15380213-ATP-Binding Cassette Transporters,
pubmed-meshheading:15380213-Antifungal Agents,
pubmed-meshheading:15380213-Candida,
pubmed-meshheading:15380213-Drug Resistance, Fungal,
pubmed-meshheading:15380213-Drug Synergism,
pubmed-meshheading:15380213-Fluconazole,
pubmed-meshheading:15380213-Fungal Proteins,
pubmed-meshheading:15380213-Humans,
pubmed-meshheading:15380213-Membrane Transport Modulators,
pubmed-meshheading:15380213-Membrane Transport Proteins,
pubmed-meshheading:15380213-Models, Molecular,
pubmed-meshheading:15380213-Piperazines,
pubmed-meshheading:15380213-Quinazolines,
pubmed-meshheading:15380213-Solubility,
pubmed-meshheading:15380213-Stereoisomerism,
pubmed-meshheading:15380213-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.
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pubmed:affiliation |
Essential Therapeutics, Inc., 850 Maude Ave., Mountain View, CA 94043, USA. remy.lemione@roche.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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