Linked Life Data

15379632

Source:http://linkedlifedata.com/resource/pubmed/id/15379632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-9-21
pubmed:abstractText
Nerve growth factor (NGF) has long been known for its effects on neuronal cell survival and differentiation. This prototypical neurotrophic factor stimulates neurons through two distinct classes of membrane receptors: the TrkA tyrosine kinase receptor, and the tumor necrosis factor receptor family member p75NTR, also known as the common neurotrophin receptor. Somewhat surprisingly, there is a growing body of evidence indicating that NGF is also a major stimulator of breast cancer cell growth. Both the survival and proliferation of breast cancer cells are strongly stimulated by NGF, mediated by TrkA and p75NTR respectively, utilising signaling pathways similar to those described for neurons. In addition, although NGF is produced by breast cancer cells, it is not in normal breast epithelial cells, giving rise to an autocrine stimulation of tumor growth. Therefore, NGF receptors and signaling are thus looking increasingly promising as potential drug targets for breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1568-0096
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Bentham Science Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
463-70
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Nerve growth factor receptors and signaling in breast cancer.
pubmed:affiliation
UPRES-EA 1033, INSERM-ESPRI "Growth Factor Signaling In Breast Cancer. Functional Proteomics", IFR-118, University of Sciences and Technologies Lille, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't