Linked Life Data

15378301

Source:http://linkedlifedata.com/resource/pubmed/id/15378301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-9-20
pubmed:abstractText
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, associated with primary destruction of myelin sheaths. Axons are relatively well preserved, although they too are injured in the development of the lesions. While inflammation and demyelination induce neurological deficit, which is in part reversible, the destruction of axons, when past the threshold of compensation, is always accompanied by irreversible clinical deficits. The mechanisms leading to tissue injury in MS are complex and heterogenous. They involve direct cytotoxicity mediated by T-lymphocytes, specific antibodies and complement as well as toxic products of macrophages. In addition, in a small subset of patients a genetically determined increased susceptibility of the central nervous system tissue for immune mediated damage appears to play a role. Since the pathogenetic pathways of demyelination and tissue damage vary between different MS patients, their identification by paraclinical markers is of critical importance for diagnosis and therapeutic management.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
251 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
IV2-5
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Recent neuropathological findings in MS--implications for diagnosis and therapy.
pubmed:affiliation
Brain Research Institute, University of Vienna, Division of Neuroimmunology, Spitalgasse 4, 1090, Vienna, Austria. hans.lassmann@univie.ac.at
pubmed:publicationType
Journal Article, Review