Linked Life Data

15378046

Source:http://linkedlifedata.com/resource/pubmed/id/15378046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-9-20
pubmed:abstractText
Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host resistance to microbial pathogens. Decades of research have provided a detailed understanding of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection. However, differences of opinion remain with regard to their host specificity, cell biology, sources and interactions with one another or with myeloperoxidase and granule proteases. More than a century after Metchnikoff first described phagocytosis, and more than four decades after the discovery of the burst of oxygen consumption that is associated with microbial killing, the seemingly elementary question of how phagocytes inhibit, kill and degrade microorganisms remains controversial. This review updates the reader on these concepts and the topical questions in the field.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1740-1526
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
820-32
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies.
pubmed:affiliation
Department of Laboratory Medicine, University of Washington School of Medicine, 1959 North East Pacific Street, Box 357242, Seattle, Washington 98195-7242, USA. fcfang@washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review