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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-3-30
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pubmed:abstractText |
The present report shows the capacity of hypothalamic extract (HE) to differentiate bone marrow cells to Thy-1+ cells in vitro. A two-step short-term culture was used. In the first step thymus and pituitary were co-cultured in the presence of HE. Supernatant was then transferred to a bone marrow cell suspension and following a period of culture, the percentage of Thy-1+ cells was determined by a microcytotoxicity assay. Results indicated that: (a) HE from young mice show a very efficient differentiating capacity; (b) HE from young mice is equally efficient when old pituitary, thymus and marrow are used; (c) HE from old donors has no capacity to differentiate T cells; (d) there is a progressive age-related decline of this capacity; and (e) there is a feed-back mechanism involved in this process. It is concluded that hypothalamic factors can regulate the differentiation of T cells and that this effect operates through a mechanism involving pituitary and thymus.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-14071261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-2984281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-3059354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-3059358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-360754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-4371105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-4542645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-4542646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-629796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-6983118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-7047671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-7397532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1537605-996449
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-102
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1537605-Aging,
pubmed-meshheading:1537605-Animals,
pubmed-meshheading:1537605-Cell Differentiation,
pubmed-meshheading:1537605-Cells, Cultured,
pubmed-meshheading:1537605-Hypothalamus,
pubmed-meshheading:1537605-Mice,
pubmed-meshheading:1537605-Mice, Inbred Strains,
pubmed-meshheading:1537605-Pituitary Gland,
pubmed-meshheading:1537605-T-Lymphocytes,
pubmed-meshheading:1537605-Thymus Gland,
pubmed-meshheading:1537605-Tissue Extracts
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pubmed:year |
1992
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pubmed:articleTitle |
Age-related capacity of neuroendocrine factors to differentiate T cells in vitro.
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pubmed:affiliation |
Department of Immunology, Universidad Austral de Chile, Valdivia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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