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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-9-17
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pubmed:abstractText |
Overexpressed Angiopoietin-2 (Ang-2) derived mainly from cancer cells was reported to promote tumor angiogenesis. The aim of this study was to evaluate the expression of Ang-2 in non-small cell lung cancers (NSCLCs). We investigated Ang-2 expression in 77 patients with NSCLC who underwent curative tumor resection by means of reverse transcription-polymerase chain reaction (RT-PCR). We also determined whether or not expression of Ang-2 mRNA correlates with immunohistochemical assays of Ang-2 protein and microvessel density (MVD) level. The level of Ang-2 mRNA expression was presented by the relative yield of each gene to the S14 mRNA, respectively. Ang-2 mRNA expression in NSCLC was significantly greater than that in non-cancerous normal lung (p=0.0178). The Ang-2 mRNA expression was significantly associated with lymph node metastasis, stage, Ang-2 protein, and microvessel density (MVD) level (p=0.0009 for lymph node metastasis; p=0.0002 for stage; p<0.0001 for Ang-2 protein; p<0.0001 for MVD). With regard to prognosis, the overall and stage I survival rates for patients in the high Ang-2 mRNA expression group were significantly poorer when compared with the low Ang-2 mRNA expression group (p<0.0001 for overall; p=0.0201 for stage I). Furthermore, expression of Ang-2 mRNA was an independent predictor of prognosis by multivariate analysis (p=0.0028). These data indicate that Ang-2 may contribute to tumor angiogenesis and progression and that Ang-2 gene expression can serve as a useful prognostic marker in NSCLC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1021-335X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
849-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15375511-Adenocarcinoma,
pubmed-meshheading:15375511-Adult,
pubmed-meshheading:15375511-Aged,
pubmed-meshheading:15375511-Aged, 80 and over,
pubmed-meshheading:15375511-Angiopoietin-2,
pubmed-meshheading:15375511-Carcinoma, Large Cell,
pubmed-meshheading:15375511-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15375511-Carcinoma, Squamous Cell,
pubmed-meshheading:15375511-Female,
pubmed-meshheading:15375511-Humans,
pubmed-meshheading:15375511-Immunoenzyme Techniques,
pubmed-meshheading:15375511-Lung Neoplasms,
pubmed-meshheading:15375511-Lymphatic Metastasis,
pubmed-meshheading:15375511-Male,
pubmed-meshheading:15375511-Microcirculation,
pubmed-meshheading:15375511-Middle Aged,
pubmed-meshheading:15375511-Neoplasm Invasiveness,
pubmed-meshheading:15375511-Neoplasm Staging,
pubmed-meshheading:15375511-Neovascularization, Pathologic,
pubmed-meshheading:15375511-Nuclear Proteins,
pubmed-meshheading:15375511-Prognosis,
pubmed-meshheading:15375511-Proteins,
pubmed-meshheading:15375511-RNA, Messenger,
pubmed-meshheading:15375511-RNA, Neoplasm,
pubmed-meshheading:15375511-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15375511-Survival Rate,
pubmed-meshheading:15375511-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis.
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pubmed:affiliation |
Department of Surgery, Teikyo University School of Medicine, Tokyo 173, Japan. takanami@med.teikyo-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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