Source:http://linkedlifedata.com/resource/pubmed/id/15375490
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-9-17
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| pubmed:abstractText |
By combining suppression subtractive hybridization and microarray to examine gene expressions between metastatic and non-metastatic non-small cell lung cancer (NSCLC), we have identified differential expression spectra of matrix metalloproteinases (MMP). Among MMPs, expressions of MMP-13, -14, -15 and -24 decreased, those of MMP-9, -11, -12, -16, -17, -19 and -23B did not change, and those of MMP-1, -2, -7, -8 and -10 increased dramatically. Overexpressions of MMP-1, -2, -7 and -10 were confirmed by reverse transcription-polymerase chain reaction. In this study we further assessed the clinical significance of MMP-1, -2, -7 and -10. Specimens from 472 patients with completely resected NSCLC were examined by immunohistochemistry. The median follow-up period was 38 months (range, 2-113 months). Overexpression of MMP-1 was observed in 72.9% (n=344) of 472 patients, that of MMP-2 was 77.9% (n=352), MMP-7 63.3% (n=299) and that of MMP-10 was 27.1% (n=128). For patients with lymph node metastasis, MMP-1 and -2 overexpressions were not only independent prognostic factors for unfavorable outcome, but also associated with decreased survival (p=0.0015, and p=0.011 respectively). The present study showed that MMP expression spectrum in NSCLC was heterogeneous: expression of some MMP increased, some unchanged, while some decreased. Therefore, it should be worth determining MMP expression pattern as a regimen reference for NSCLC patients who were scheduled to receive MMP inhibitor, which was class-specific, as adjuvant therapeutic agent.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
1021-335X
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| pubmed:author |
pubmed-author:ChenChih-YiCY,
pubmed-author:ChenYa-LinYL,
pubmed-author:ChiangShu-FenSF,
pubmed-author:ChiouShiow-HerSH,
pubmed-author:ChouMing-ChihMC,
pubmed-author:ChowKuan-ChihKC,
pubmed-author:HsuChung-PingCP,
pubmed-author:HsuNan-YungNY,
pubmed-author:HuangHsuan-HuaHH,
pubmed-author:KuoShou-JenSJ,
pubmed-author:LinTorng-SenTS,
pubmed-author:ShihAlex Y HAY,
pubmed-author:WangLiang-ShunLS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
717-23
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15375490-Adult,
pubmed-meshheading:15375490-Aged,
pubmed-meshheading:15375490-Aged, 80 and over,
pubmed-meshheading:15375490-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15375490-DNA, Complementary,
pubmed-meshheading:15375490-Female,
pubmed-meshheading:15375490-Gene Expression Profiling,
pubmed-meshheading:15375490-Humans,
pubmed-meshheading:15375490-Immunoenzyme Techniques,
pubmed-meshheading:15375490-In Situ Hybridization,
pubmed-meshheading:15375490-Lung Neoplasms,
pubmed-meshheading:15375490-Male,
pubmed-meshheading:15375490-Matrix Metalloproteinases,
pubmed-meshheading:15375490-Microarray Analysis,
pubmed-meshheading:15375490-Middle Aged,
pubmed-meshheading:15375490-Neoplasm Invasiveness,
pubmed-meshheading:15375490-Neoplasm Staging,
pubmed-meshheading:15375490-Nucleic Acid Hybridization,
pubmed-meshheading:15375490-Prognosis,
pubmed-meshheading:15375490-RNA, Neoplasm,
pubmed-meshheading:15375490-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15375490-Subtraction Technique,
pubmed-meshheading:15375490-Survival Rate,
pubmed-meshheading:15375490-Tumor Markers, Biological
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer.
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| pubmed:affiliation |
Department of Surgery, Chang-Hua Christian Hospital, and Institute of Medicine, Chang-Shan Medical University, Taichung, Taiwan.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|