Linked Life Data

15375267

Source:http://linkedlifedata.com/resource/pubmed/id/15375267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5691
pubmed:dateCreated
2004-9-17
pubmed:abstractText
Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood. We have created a transgenic line of mice (PHIL) that are specifically devoid of eosinophils, but otherwise have a full complement of hematopoietically derived cells. Allergen challenge of PHIL mice demonstrated that eosinophils were required for pulmonary mucus accumulation and the airway hyperresponsiveness associated with asthma. The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1773-6
pubmed:dateRevised
2010-8-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Defining a link with asthma in mice congenitally deficient in eosinophils.
pubmed:affiliation
Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. jjlee@mayo.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't