Linked Life Data

15374991

Source:http://linkedlifedata.com/resource/pubmed/id/15374991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2004-9-17
pubmed:abstractText
Breast cancer is still one of the most important tumors among women in industrialized countries. Improvement in both understanding the molecular events associated with the disease and the development of new additional treatments is still an important goal to be achieved. Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. Furthermore, inhibition of ChoK shows a strong in vivo antitumor activity against human breast cancer xenografts. Thus, ChoK constitutes a novel bona fide molecular target for the treatment of breast cancer patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6732-9
pubmed:dateRevised
2007-9-25
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.
pubmed:affiliation
Department of Molecular and Cellular Biology of Cancer, Translational Oncology Unit, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Cicutíficas, Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't