Source:http://linkedlifedata.com/resource/pubmed/id/15374844
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-11-9
|
| pubmed:abstractText |
This nested case-control study aimed at evaluating treatment-related risk factors of relapse of tuberculosis under a service program of directly observed treatment. Out of 12,183 patients with pulmonary tuberculosis who completed treatment within 1 year, 113 relapsed within 30 months after commencement of therapy. The overall 30-month relapse rate was 0.9% (95% confidence interval [CI] 0.8-1.1%). On matching 113 cases with 226 control subjects in a conditional logistic model, thrice-weekly treatment increased the risk of relapse in comparison with daily treatment (odds ratio 3.92, 95% CI 1.78-8.63), whereas prolonging both intensive phase and overall treatment by 50% or more protected against relapse (odds ratio 0.24, 95% CI 0.08-0.70). When pretreatment culture was positive and cavitation was absent, the 30-month relapse rate for standard thrice-weekly regimen was 1.1% (95% CI 0.6-2.0%). The corresponding rates in the presence of cavitation were 7.8% (95% CI 4.0-14.6%) for standard thrice-weekly regimen; 3.3% (95% CI 1.9-5.5%) for standard daily regimen; 0.5% (95% CI 0.1-2.6%) for extended thrice-weekly regimen; and 0.4% (95% CI 0.1-0.9%) for extended daily regimen. Further studies are required to reduce the risk of relapse under program settings.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1073-449X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1124-30
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15374844-Adult,
pubmed-meshheading:15374844-Age Distribution,
pubmed-meshheading:15374844-Aged,
pubmed-meshheading:15374844-Analysis of Variance,
pubmed-meshheading:15374844-Antitubercular Agents,
pubmed-meshheading:15374844-Case-Control Studies,
pubmed-meshheading:15374844-Directly Observed Therapy,
pubmed-meshheading:15374844-Dose-Response Relationship, Drug,
pubmed-meshheading:15374844-Drug Administration Schedule,
pubmed-meshheading:15374844-Female,
pubmed-meshheading:15374844-Follow-Up Studies,
pubmed-meshheading:15374844-Hong Kong,
pubmed-meshheading:15374844-Humans,
pubmed-meshheading:15374844-Incidence,
pubmed-meshheading:15374844-Logistic Models,
pubmed-meshheading:15374844-Male,
pubmed-meshheading:15374844-Middle Aged,
pubmed-meshheading:15374844-Recurrence,
pubmed-meshheading:15374844-Reference Values,
pubmed-meshheading:15374844-Retrospective Studies,
pubmed-meshheading:15374844-Risk Assessment,
pubmed-meshheading:15374844-Severity of Illness Index,
pubmed-meshheading:15374844-Sex Distribution,
pubmed-meshheading:15374844-Time Factors,
pubmed-meshheading:15374844-Treatment Outcome,
pubmed-meshheading:15374844-Tuberculosis, Pulmonary
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
A nested case-control study on treatment-related risk factors for early relapse of tuberculosis.
|
| pubmed:affiliation |
Tuberculosis and Chest Service, Department of Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China. ymtcc@dh.gov.hk
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|