Linked Life Data

15374529

Source:http://linkedlifedata.com/resource/pubmed/id/15374529

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15374529rdf:typepubmed:Citationlld:pubmed
pubmed-article:15374529lifeskim:mentionsumls-concept:C0008059lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0026882lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0012314lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0024535lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0039667lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0231174lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0681842lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0205468lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0205195lld:lifeskim
pubmed-article:15374529lifeskim:mentionsumls-concept:C0700599lld:lifeskim
pubmed-article:15374529pubmed:issue4lld:pubmed
pubmed-article:15374529pubmed:dateCreated2004-9-17lld:pubmed
pubmed-article:15374529pubmed:abstractTextThe point mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) and the dihydropteroate synthase (dhps) genes that are linked to sulphadoxine-pyrimethamine (SP) resistance in vitro have been well characterised. To determine whether a few of these mutations could predict SP treatment failure in vivo, two mutations (Asn-108 and Arg-59) in the dhfr gene and one (Glu-540) in the dhps gene were analysed according to the risk of SP parasitological failure (RI-RIII) at day 28 in pre-treatment isolates in 79 Ugandan children aged 6-59 (mean = 18.4, S.D. = 8.8) months with uncomplicated falciparum malaria. Neither the dhfr-108 (P = 0.3) nor the dhps-540 (P = 0.6) or dhfr-108 + dhps-540 (P = 0.04) mutations were significantly associated with SP parasitological failure. However, the dhfr-108 + dhfr-59 (P = 0.04), the dhfr-59 + dhps-540 (P = 0.04) and the dhfr-108 + dhfr-59 + dhps-540 (P = 0.02) mutations significantly increased the risk for SP parasitological failure. Our findings confirm an earlier report that the dhfr-59 and the dhps-540 mutations could be useful genetic markers for rapid screening of populations at high risk of SP resistance.lld:pubmed
pubmed-article:15374529pubmed:languageenglld:pubmed
pubmed-article:15374529pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:citationSubsetIMlld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15374529pubmed:statusMEDLINElld:pubmed
pubmed-article:15374529pubmed:monthDeclld:pubmed
pubmed-article:15374529pubmed:issn1567-1348lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:Van...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:EgwangThomas...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:MutabingwaThe...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:TalisunaAmbro...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:LangiPeterPlld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:D'AlessandroU...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:WatkinsWillia...lld:pubmed
pubmed-article:15374529pubmed:authorpubmed-author:Nalunkuma-Kaz...lld:pubmed
pubmed-article:15374529pubmed:issnTypePrintlld:pubmed
pubmed-article:15374529pubmed:volume4lld:pubmed
pubmed-article:15374529pubmed:ownerNLMlld:pubmed
pubmed-article:15374529pubmed:authorsCompleteYlld:pubmed
pubmed-article:15374529pubmed:pagination321-7lld:pubmed
pubmed-article:15374529pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:meshHeadingpubmed-meshheading:15374529...lld:pubmed
pubmed-article:15374529pubmed:year2004lld:pubmed
pubmed-article:15374529pubmed:articleTitleTwo mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria.lld:pubmed
pubmed-article:15374529pubmed:affiliationMinistry of Health, Epidemiological Surveillance Division, P. O. Box 7272, Kampala, Uganda, Belgium. atalisuna@yahoo.comlld:pubmed
pubmed-article:15374529pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15374529pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15374529lld:pubmed