Source:http://linkedlifedata.com/resource/pubmed/id/15374529
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-9-17
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| pubmed:abstractText |
The point mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) and the dihydropteroate synthase (dhps) genes that are linked to sulphadoxine-pyrimethamine (SP) resistance in vitro have been well characterised. To determine whether a few of these mutations could predict SP treatment failure in vivo, two mutations (Asn-108 and Arg-59) in the dhfr gene and one (Glu-540) in the dhps gene were analysed according to the risk of SP parasitological failure (RI-RIII) at day 28 in pre-treatment isolates in 79 Ugandan children aged 6-59 (mean = 18.4, S.D. = 8.8) months with uncomplicated falciparum malaria. Neither the dhfr-108 (P = 0.3) nor the dhps-540 (P = 0.6) or dhfr-108 + dhps-540 (P = 0.04) mutations were significantly associated with SP parasitological failure. However, the dhfr-108 + dhfr-59 (P = 0.04), the dhfr-59 + dhps-540 (P = 0.04) and the dhfr-108 + dhfr-59 + dhps-540 (P = 0.02) mutations significantly increased the risk for SP parasitological failure. Our findings confirm an earlier report that the dhfr-59 and the dhps-540 mutations could be useful genetic markers for rapid screening of populations at high risk of SP resistance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropteroate Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimethamine,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfadoxine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolate Dehydrogenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1567-1348
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
321-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15374529-Animals,
pubmed-meshheading:15374529-Antimalarials,
pubmed-meshheading:15374529-Child, Preschool,
pubmed-meshheading:15374529-Dihydropteroate Synthase,
pubmed-meshheading:15374529-Drug Combinations,
pubmed-meshheading:15374529-Drug Resistance,
pubmed-meshheading:15374529-Follow-Up Studies,
pubmed-meshheading:15374529-Humans,
pubmed-meshheading:15374529-Infant,
pubmed-meshheading:15374529-Malaria, Falciparum,
pubmed-meshheading:15374529-Plasmodium falciparum,
pubmed-meshheading:15374529-Point Mutation,
pubmed-meshheading:15374529-Pyrimethamine,
pubmed-meshheading:15374529-Retrospective Studies,
pubmed-meshheading:15374529-Sulfadoxine,
pubmed-meshheading:15374529-Tetrahydrofolate Dehydrogenase,
pubmed-meshheading:15374529-Time Factors,
pubmed-meshheading:15374529-Treatment Failure,
pubmed-meshheading:15374529-Uganda
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| pubmed:year |
2004
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| pubmed:articleTitle |
Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria.
|
| pubmed:affiliation |
Ministry of Health, Epidemiological Surveillance Division, P. O. Box 7272, Kampala, Uganda, Belgium. atalisuna@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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