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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-3-27
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pubmed:abstractText |
Tyrosine phosphorylation in human blood lymphocytes was studied as a function of stimulation with concanavalin A (ConA) and treatment of the cells with interferon alpha 2 (IFN alpha 2) and/or an IFN-derived C-terminal synthetic peptide 2438 (amino acid residues 124-138). Both IFN alpha 2 and the peptide 2438 decreased the level of protein tyrosine phosphorylation in the ConA-stimulated cells. In unstimulated cells, IFN alpha 2 increased, and the peptide 2438 decreased the level of the tyrosine phosphorylation. A possible correlation of these effects with stimulation of cell proliferation is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1537402-Blotting, Western,
pubmed-meshheading:1537402-Cell Division,
pubmed-meshheading:1537402-Cells, Cultured,
pubmed-meshheading:1537402-Humans,
pubmed-meshheading:1537402-Interferon Type I,
pubmed-meshheading:1537402-Leukocytes,
pubmed-meshheading:1537402-Peptide Fragments,
pubmed-meshheading:1537402-Peptides,
pubmed-meshheading:1537402-Phosphorylation,
pubmed-meshheading:1537402-Protein-Tyrosine Kinases,
pubmed-meshheading:1537402-Recombinant Proteins,
pubmed-meshheading:1537402-Tyrosine
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pubmed:year |
1992
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pubmed:articleTitle |
Interaction of a synthetic peptide of the interferon alpha 2 C-terminal part with human blood leukocytes. II. Effect on protein tyrosine phosphorylation.
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pubmed:affiliation |
Moscow State University, Biological Faculty, USSR.
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pubmed:publicationType |
Journal Article
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