Linked Life Data

15372666

Source:http://linkedlifedata.com/resource/pubmed/id/15372666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2004-9-29
pubmed:abstractText
Oxidative damage of DNA via radical cation formation is a common cause of mutagenesis, cancer and of the physiological changes associated with aging. By using state-of-the-art ab initio molecular dynamics simulations, we study the mechanism that guides the first steps of this process. In the mechanism proposed here, guanine, which among the bases has the lowest oxidation potential, and the phosphate backbone play a crucial role. We found that the rate limiting step is the water protolysis. We illuminate the role of the local environment in considerably lowering the barrier. Of particular relevance in this respect is the role of the phosphate backbone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0947-6539
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4846-52
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Influence of DNA structure on the reactivity of the guanine radical cation.
pubmed:affiliation
Laboratory of Physical Chemistry, ETH Zürich, USI Campus via Giuseppe Buffi 13, 6904 Lugano, Switzerland. fgervasi@phys.chem.ethz.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't