Linked Life Data

1537169

Source:http://linkedlifedata.com/resource/pubmed/id/1537169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
276
pubmed:dateCreated
1992-4-2
pubmed:abstractText
Chick tibial periosteal cells were enzymatically disaggregated, introduced into cell culture, and subcultured. These subcultured cells were combined with porous calcium phosphate ceramics and implanted into a subcutaneous site in athymic mice as an immunocompatible host to test the in vivo osteochondrogenic potential of this composite graft. These cells eventually gave rise to bone tissue in the pores of ceramics at the heterotopic implantation sites. The process of bone formation occurred through two different mechanisms: Intramembranous bone formation occurred at the peripheral pores of ceramics early, and endochondral bone formation occurred in the central pores later. Cultured chick muscle fibroblasts of the same-aged donor as controls did not form bone or cartilage under identical conditions to those of cultured periosteal-derived cells. These results raise the possibility that composite graft of cultured periosteal-derived cells and porous ceramics can be clinically used as a bone graft substitute in situations requiring bone augmentation or regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Culture-expanded periosteal-derived cells exhibit osteochondrogenic potential in porous calcium phosphate ceramics in vivo.
pubmed:affiliation
Department of Biology, Case Western Reserve University, Cleveland, Ohio.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.