Linked Life Data

15369383

Source:http://linkedlifedata.com/resource/pubmed/id/15369383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2004-9-16
pubmed:abstractText
Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4810-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15369383-Antineoplastic Agents, pubmed-meshheading:15369383-Binding Sites, pubmed-meshheading:15369383-Cell Division, pubmed-meshheading:15369383-Cysteine Endopeptidases, pubmed-meshheading:15369383-Cysteine Proteinase Inhibitors, pubmed-meshheading:15369383-Drug Screening Assays, Antitumor, pubmed-meshheading:15369383-Humans, pubmed-meshheading:15369383-Hydrogen Bonding, pubmed-meshheading:15369383-Inhibitory Concentration 50, pubmed-meshheading:15369383-Models, Molecular, pubmed-meshheading:15369383-Molecular Structure, pubmed-meshheading:15369383-Multienzyme Complexes, pubmed-meshheading:15369383-Oligopeptides, pubmed-meshheading:15369383-Proteasome Endopeptidase Complex, pubmed-meshheading:15369383-Structure-Activity Relationship, pubmed-meshheading:15369383-Tumor Cells, Cultured
pubmed:year
2004
pubmed:articleTitle
Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.
pubmed:affiliation
Novartis Pharma AG, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
pubmed:publicationType
Journal Article