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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2004-9-16
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pubmed:abstractText |
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or C-7 position and were found to be very cytotoxic against both normal and multi-drug-resistant (MDR) cells, as well as up to 30 times more soluble than paclitaxel in various buffer systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4802-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:15369381-Antineoplastic Agents,
pubmed-meshheading:15369381-Biochemistry,
pubmed-meshheading:15369381-Breast Neoplasms,
pubmed-meshheading:15369381-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15369381-Disulfides,
pubmed-meshheading:15369381-Drug Carriers,
pubmed-meshheading:15369381-Drug Resistance, Multiple,
pubmed-meshheading:15369381-Drug Resistance, Neoplasm,
pubmed-meshheading:15369381-Drug Screening Assays, Antitumor,
pubmed-meshheading:15369381-Female,
pubmed-meshheading:15369381-Humans,
pubmed-meshheading:15369381-Lung Neoplasms,
pubmed-meshheading:15369381-Paclitaxel,
pubmed-meshheading:15369381-Polyethylene Glycols,
pubmed-meshheading:15369381-Solubility,
pubmed-meshheading:15369381-Structure-Activity Relationship,
pubmed-meshheading:15369381-Taxoids,
pubmed-meshheading:15369381-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.
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pubmed:affiliation |
ImmunoGen, Inc., 128 Sidney Street, Cambridge, Massachussetts 02139, USA.
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pubmed:publicationType |
Journal Article
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