Source:http://linkedlifedata.com/resource/pubmed/id/15368589
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2004-10-6
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| pubmed:abstractText |
Malignant glioma has a dismal prognosis. It was previously shown that glioma cells are efficiently killed when they express a gene coding for a hyperfusogenic mutant of the gibbon ape leukemia virus envelope glycoprotein (GALV.fus). However, production of viral vectors expressing GALV.fus has proven problematic because the transgene is toxic to vector-producing cells of human origin. We reasoned that Sindbis-virus-based vectors might be ideal for GALV.fus gene transfer because high-titer stocks can easily be generated in hamster cells and Sindbis virus efficiently infects human tumor cells through the high-affinity 67 kDa laminin receptor. In addition, Sindbis virus nonstructural proteins are potent inducers of apoptosis, and Sindbis vector RNAs expressing fusogenic viral proteins have been shown to spread from cell-to-cell in membrane-formed infectious particles.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1099-498X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1082-91
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15368589-Animals,
pubmed-meshheading:15368589-Antineoplastic Agents,
pubmed-meshheading:15368589-Brain Neoplasms,
pubmed-meshheading:15368589-Cell Line,
pubmed-meshheading:15368589-Cell Line, Tumor,
pubmed-meshheading:15368589-Cricetinae,
pubmed-meshheading:15368589-DNA Fragmentation,
pubmed-meshheading:15368589-Gene Therapy,
pubmed-meshheading:15368589-Gene Transfer Techniques,
pubmed-meshheading:15368589-Genetic Vectors,
pubmed-meshheading:15368589-Glioma,
pubmed-meshheading:15368589-Humans,
pubmed-meshheading:15368589-In Situ Nick-End Labeling,
pubmed-meshheading:15368589-Lac Operon,
pubmed-meshheading:15368589-Membrane Glycoproteins,
pubmed-meshheading:15368589-Mice,
pubmed-meshheading:15368589-Mice, Nude,
pubmed-meshheading:15368589-Models, Genetic,
pubmed-meshheading:15368589-Neoplasm Transplantation,
pubmed-meshheading:15368589-Plasmids,
pubmed-meshheading:15368589-Sindbis Virus,
pubmed-meshheading:15368589-Time Factors,
pubmed-meshheading:15368589-beta-Galactosidase
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein.
|
| pubmed:affiliation |
Mayo Clinic, Molecular Medicine Program, 200 First Street, SW, Rochester, MN 55905, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|