Source:http://linkedlifedata.com/resource/pubmed/id/15368517
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-9-24
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| pubmed:abstractText |
Chronic active Epstein-Barr virus (EBV) infection is a chronic mononucleosis syndrome associated with clonal proliferation of EBV-carrying T-/natural killer (NK)-cells. High levels of circulating EBV and activated T-cells are sustained during the prolonged disease course, whereas it is not clear how ectopic EBV infection in T-/NK-cells has been established and maintained. To assess the biological role of activated T-cells in chronic active EBV infection (CAEBV), EBV DNA and cellular gene expressions in peripheral T-cells were quantified in CAEBV and infectious mononucleosis (IM) patients. In CAEBV, HLA-DR(+) T-cells had higher viral load and larger amounts of IFN gamma, IL-10, transforming growth factor-beta (TGF beta), and cytotoxic T lymphocyte antigen-4 (CTLA4) mRNA than HLA-DR(-)T-cells. HLA-DR(+) T cells of IM patients transcribed more IFN gamma and IL-10 than their HLA-DR(-)T cells. Expression levels of IFN gamma and forkhead box p3 (Foxp3) in CAEBV HLA-DR(+) T-cells were higher than in IM HLA-DR(+) T-cells. The effective variables to discriminate the positivity of HLA-DR were IL-10, IFN gamma, CTLA4, TGF beta, and IL-2 in the order of statistical weight. EBV load in CAEBV T-cells correlated with the expression levels of only IL-10 and TGF beta. These results suggest that CAEBV T-cells are activated to transcribe IFN gamma, IL-10, and TGF beta excessively, and the latter two genes are expressed preferentially in the EBV-infected subsets. The dominant expression of regulatory cytokines in T-cells may imply a viral evasion mechanism in the disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0146-6615
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
74
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
449-58
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15368517-Adolescent,
pubmed-meshheading:15368517-Adult,
pubmed-meshheading:15368517-Base Sequence,
pubmed-meshheading:15368517-Child,
pubmed-meshheading:15368517-Child, Preschool,
pubmed-meshheading:15368517-Chronic Disease,
pubmed-meshheading:15368517-Epstein-Barr Virus Infections,
pubmed-meshheading:15368517-Female,
pubmed-meshheading:15368517-Gene Expression,
pubmed-meshheading:15368517-Herpesvirus 4, Human,
pubmed-meshheading:15368517-Humans,
pubmed-meshheading:15368517-Infant,
pubmed-meshheading:15368517-Interferon-gamma,
pubmed-meshheading:15368517-Interleukin-10,
pubmed-meshheading:15368517-Lymphocyte Activation,
pubmed-meshheading:15368517-Male,
pubmed-meshheading:15368517-RNA, Messenger,
pubmed-meshheading:15368517-T-Lymphocytes,
pubmed-meshheading:15368517-Transforming Growth Factor beta
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Dominant expression of interleukin-10 and transforming growth factor-beta genes in activated T-cells of chronic active Epstein-Barr virus infection.
|
| pubmed:affiliation |
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ohgas@pediatr.med.kyushu-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|