Source:http://linkedlifedata.com/resource/pubmed/id/15368285
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-9-15
|
| pubmed:abstractText |
Inflammatory bowel disease (IBD) is prevalent in industrialized countries, but rare in less-developed countries. Helminths, common in less-developed countries, may induce immunoregulatory circuits protective against IBD. IL-10(-/-) mice given piroxicam develop severe and persistent colitis. Lamina propria mononuclear cells from colitic IL-10(-/-) mice released IFN-gamma and IL-12. The ongoing piroxicam-induced colitis could be partially blocked with anti-IL-12 monoclonal antibody suggesting that the inflammation was at least partly IL-12 dependent. Colonization of piroxicam-treated colitic IL-10(-/-) mice with Heligmosomoides polygyrus (an intestinal helminth) suppressed established inflammation and inhibited mucosal IL-12 and IFN-gamma production. H. polygyrus augmented mucosal IL-13, but not IL-4 or IL-5 production. Transfer of mesenteric lymph node (MLN) T cells from IL-10(-/-) animals harboring H. polygyrus into colitic IL-10(-/-) recipients inhibited colitis. MLN T cells from worm-free mice did not. Foxp3 (scurfin) drives regulatory T cell function. H. polygyrus enhanced Foxp3 mRNA expression in MLN T cells that had regulatory activity. This suggests that H. polygyrus inhibits ongoing IL-10(-/-) colitis in part through blocking mucosal Th1 cytokine production. Resolution of inflammation is associated with increased IL-13 production and can be adoptively transferred by MLN T cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Piroxicam,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2690-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:15368285-Adoptive Transfer,
pubmed-meshheading:15368285-Animals,
pubmed-meshheading:15368285-Colitis,
pubmed-meshheading:15368285-Cyclooxygenase Inhibitors,
pubmed-meshheading:15368285-DNA-Binding Proteins,
pubmed-meshheading:15368285-Disease Models, Animal,
pubmed-meshheading:15368285-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15368285-Flow Cytometry,
pubmed-meshheading:15368285-Forkhead Transcription Factors,
pubmed-meshheading:15368285-Interferon-gamma,
pubmed-meshheading:15368285-Interleukin-10,
pubmed-meshheading:15368285-Interleukin-12,
pubmed-meshheading:15368285-Intestinal Mucosa,
pubmed-meshheading:15368285-Mice,
pubmed-meshheading:15368285-Nematospiroides dubius,
pubmed-meshheading:15368285-Piroxicam,
pubmed-meshheading:15368285-RNA, Messenger,
pubmed-meshheading:15368285-Strongylida Infections,
pubmed-meshheading:15368285-Th1 Cells
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice.
|
| pubmed:affiliation |
Department of Internal Medicine, Division of Gastroenterology-Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA. david-elliott@uiowa.edu
|
| pubmed:publicationType |
Journal Article
|