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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-3-24
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pubmed:abstractText |
The effects of aniso-osmotically and amino-acid-induced cell-volume changes on bile flow and biliary taurocholate excretion were studied in isolated perfused rat liver. With taurocholate (100 microM) in the influent perfusate, hypo-osmotic exposure (225 mosmol/l) increased taurocholate excretion into bile and bile flow by 42 and 27% respectively, whereas inhibition by 32 and 47% respectively was observed after hyperosmotic (385 mosmol/l) exposure. The effects of aniso-moticity on taurocholate excretion into bile was observed throughout aniso-osmotic exposure, even after completion of volume-regulatory ion fluxes and were fully reversible upon re-exposure to normo-osmotic media. Hypo-osmotic cell swelling (225 mosmol/l) increased the Vmax. of taurocholate translocation from the sinusoidal compartment into bile about 2-fold. Also, cell swelling induced by glutamine and glycine stimulated both bile flow and biliary taurocholate excretion. There was a close relationship between the aniso-osmotically and amino-acid-induced change of cell volume and taurocholate excretion into bile. The data suggest that liver cell volume plays an important role in regulating bile-acid-dependent bile flow and biliary taurocholate excretion.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-1661157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-1910579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-1916666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-2019573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-2156294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-2249700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-2493745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-2717371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-3074399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-6480708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-672651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1536640-7118069
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
281 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1536640-Amino Acids,
pubmed-meshheading:1536640-Animals,
pubmed-meshheading:1536640-Bile,
pubmed-meshheading:1536640-Hypotonic Solutions,
pubmed-meshheading:1536640-Liver,
pubmed-meshheading:1536640-Male,
pubmed-meshheading:1536640-Perfusion,
pubmed-meshheading:1536640-Rats,
pubmed-meshheading:1536640-Rats, Inbred Strains,
pubmed-meshheading:1536640-Saline Solution, Hypertonic,
pubmed-meshheading:1536640-Sodium Chloride,
pubmed-meshheading:1536640-Taurocholic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Cell swelling increases bile flow and taurocholate excretion into bile in isolated perfused rat liver.
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pubmed:affiliation |
Medizinische Universitätsklinik, Freiburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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