Galanin and its receptors exert inhibitory neuromodulatory control over brain monoamines. Rat studies revealed that galanin expression is upregulated by exposure to stressors and that galanin manipulations modify neuroendocrine and behavioral responses to stress, leading to the hypothesis that galanin mediates depression-related behaviors.
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Building 10, Room 3C217, Bethesda, MD 20892-1375, USA. holmesan@mail.nih.gov
