Linked Life Data

15365366

Source:http://linkedlifedata.com/resource/pubmed/id/15365366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-9-14
pubmed:abstractText
Pigmented actinic keratosis is one of the simulators of early melanoma in situ from severely sun-damaged skin. Close scrutiny of the hematoxylin and eosin stained section does not always allow an unequivocal diagnosis, because it is sometimes difficult to distinguish pigmented keratinocytes from melanocytes. Immunohistochemical stains, such as S-100 and HMB-45, are used routinely to address this problem. Melan-A, also known as MART-1, is an additional melanocytic marker and has proved to be useful in identifying metastatic tumors of melanocytic origin. The usefulness of this marker to discriminate pigmented actinic keratosis from early melanoma in situ, however, has not yet been a subject of investigation. In this study we evaluated Melan-A expression in ten unequivocal cases of pigmented actinic keratosis and compared the staining pattern with that of S-100, HMB-45, and tyrosinase. In all ten cases the number of cells highlighted with Melan-A was by far larger than those labeled with S-100, HMB-45, and tyrosinase. Four cases showed clusters of Melan-A positive cells being suggestive of melanocytic nests. Even areas of normal skin adjacent to the actinic keratosis featured prominent staining of Melan-A, but only inconsistent labeling of intraepidermal melanocytes with S-100, HMB-45, and tyrosinase. We therefore believe that Melan-A is a more sensitive marker for intraepidermal melanocytes than S-100, HMB-45, and tyrosinase. In addition there may be expression of Melan-A in keratinocytes and nonmelanocytic cells. To avoid an erroneous diagnosis of malignant melanoma one should therefore interpret results obtained from Melan-A stained slides carefully and in the context with other melanocytic markers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0193-1091
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
364-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15365366-Aged, pubmed-meshheading:15365366-Aged, 80 and over, pubmed-meshheading:15365366-Antigens, Neoplasm, pubmed-meshheading:15365366-Carcinoma in Situ, pubmed-meshheading:15365366-Diagnosis, Differential, pubmed-meshheading:15365366-Female, pubmed-meshheading:15365366-Humans, pubmed-meshheading:15365366-Immunohistochemistry, pubmed-meshheading:15365366-Keratosis, pubmed-meshheading:15365366-MART-1 Antigen, pubmed-meshheading:15365366-Male, pubmed-meshheading:15365366-Melanoma, pubmed-meshheading:15365366-Melanoma-Specific Antigens, pubmed-meshheading:15365366-Middle Aged, pubmed-meshheading:15365366-Monophenol Monooxygenase, pubmed-meshheading:15365366-Neoplasm Proteins, pubmed-meshheading:15365366-S100 Proteins, pubmed-meshheading:15365366-Skin Neoplasms, pubmed-meshheading:15365366-Sunlight, pubmed-meshheading:15365366-Tumor Markers, Biological
pubmed:year
2004
pubmed:articleTitle
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.
pubmed:affiliation
Department of Dermatology, University of Graz, 8036 Graz, Austria.
pubmed:publicationType
Journal Article, Comparative Study