rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-9-14
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pubmed:abstractText |
Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
913-5
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:15365149-Age of Onset,
pubmed-meshheading:15365149-Alleles,
pubmed-meshheading:15365149-Alzheimer Disease,
pubmed-meshheading:15365149-Apolipoprotein E4,
pubmed-meshheading:15365149-Apolipoproteins E,
pubmed-meshheading:15365149-Brain,
pubmed-meshheading:15365149-Brain Mapping,
pubmed-meshheading:15365149-Female,
pubmed-meshheading:15365149-Genotype,
pubmed-meshheading:15365149-Humans,
pubmed-meshheading:15365149-Male,
pubmed-meshheading:15365149-Memory Disorders,
pubmed-meshheading:15365149-Mental Recall,
pubmed-meshheading:15365149-Middle Aged,
pubmed-meshheading:15365149-Neuropsychological Tests,
pubmed-meshheading:15365149-Pattern Recognition, Visual,
pubmed-meshheading:15365149-Positron-Emission Tomography
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pubmed:year |
2004
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pubmed:articleTitle |
APOE-dependent PET patterns of brain activation in Alzheimer disease.
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pubmed:affiliation |
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University; New York, NY 10032, USA. ns257@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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