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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-9-14
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pubmed:abstractText |
Repetitive activation of glutamatergic fibers that normally induces long-term potentiation (LTP) at excitatory synapses in the hippocampus also triggers long-term depression at inhibitory synapses (I-LTD) via retrograde endocannabinoid signaling. Little is known, however, about the physiological significance of I-LTD. Here, we show that synaptic-driven release of endocannabinoids is a highly localized and efficient process that strongly depresses cannabinoid-sensitive inhibitory inputs within the dendritic compartment of CA1 pyramidal cells. By removing synaptic inhibition in a restricted area of the dendritic tree, endocannabinoids selectively "primed" nearby excitatory synapses, thereby facilitating subsequent induction of LTP. This induction of local metaplasticity is a novel mechanism by which endocannabinoids can contribute to the storage of information in the brain.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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|
pubmed:issn |
0896-6273
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
16
|
|
pubmed:volume |
43
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
871-81
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15363397-Animals,
pubmed-meshheading:15363397-Dose-Response Relationship, Radiation,
pubmed-meshheading:15363397-Electric Stimulation,
pubmed-meshheading:15363397-Endocannabinoids,
pubmed-meshheading:15363397-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15363397-Excitatory Postsynaptic Potentials,
pubmed-meshheading:15363397-GABA Antagonists,
pubmed-meshheading:15363397-Hippocampus,
pubmed-meshheading:15363397-Long-Term Synaptic Depression,
pubmed-meshheading:15363397-Mice,
pubmed-meshheading:15363397-Mice, Inbred C57BL,
pubmed-meshheading:15363397-Mice, Knockout,
pubmed-meshheading:15363397-Neural Inhibition,
pubmed-meshheading:15363397-Neuronal Plasticity,
pubmed-meshheading:15363397-Neurons,
pubmed-meshheading:15363397-Picrotoxin,
pubmed-meshheading:15363397-Piperidines,
pubmed-meshheading:15363397-Pyrazoles,
pubmed-meshheading:15363397-Receptor, Cannabinoid, CB1,
pubmed-meshheading:15363397-Synapses,
pubmed-meshheading:15363397-Time Factors
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pubmed:year |
2004
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|
pubmed:articleTitle |
Endocannabinoid-mediated metaplasticity in the hippocampus.
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pubmed:affiliation |
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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