Linked Life Data

15363151

Source:http://linkedlifedata.com/resource/pubmed/id/15363151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-9-14
pubmed:abstractText
The autoantigenic epitopes carried by the platelet glycoprotein in patients with idiopathic thrombocytopenic purpura (ITP) have been observed to localize on the specific regions of glycoprotein. There is a limited number of autoantigenic epitopes on the respective glycoproteins. The clonal B-cell and/or T cell expansion have been detected in some patients with ITP, and the autoantibodies is clonally derived. This research is of clinical importance since identification of clonally derived autoantibodies not only may help to discover the pathogenesis of ITP but also lead to less toxic and more specific therapies. In this review, the clonal limitation of autoantibody and clonal expansion of B-lymphocyte is ITP, clonal characteristics of T-lymphocyte in ITP, and significance of research on clones in ITP were discussed and summarized.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1009-2137
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
538-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
[Study on the clonal characteristics of idiopathic thrombocytopenic purpura-review].
pubmed:affiliation
Department of Hematology, Oncology Center, Qilu Hospital, Shandong University, Shandong 250012, China. houming@medmail.com.cn
pubmed:publicationType
Journal Article, English Abstract, Review