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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-9-29
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pubmed:abstractText |
Cd79a (called mb-1 here) encodes the Ig-alpha signaling component of the B cell receptor. The early B cell-specific mb-1 promoter was hypermethylated at CpG dinucleotides in hematopoietic stem cells but became progressively unmethylated as B cell development proceeded. The transcription factor Pax5 activated endogenous mb-1 transcription in a plasmacytoma cell line, but could not when the promoter was methylated. In this context, early B cell factor (EBF), a transcription factor required for B lymphopoiesis, potentiated activation of mb-1 by Pax5. EBF and the basic helix-loop-helix transcription factor E47 each contributed to epigenetic modifications of the mb-1 promoter, including CpG demethylation and nucleosomal remodeling. EBF function was enhanced by interaction with the transcription factor Runx1. These data suggest a molecular basis for the hierarchical dependence of Pax5 function on EBF and E2A in B lymphocyte development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD79,
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell-Specific Activator Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cd79a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ebf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pax5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Runx1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:FieldsScottS,
pubmed-author:HagmanJamesJ,
pubmed-author:HardyRichard RRR,
pubmed-author:IkawaTomokatsuT,
pubmed-author:MaierHollyH,
pubmed-author:MedinaKay LKL,
pubmed-author:MurreCornelisC,
pubmed-author:OstraatRachelR,
pubmed-author:RERR,
pubmed-author:ShintonSusan ASA,
pubmed-author:SinghHarinderH
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1069-77
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15361869-Animals,
pubmed-meshheading:15361869-Antigens, CD,
pubmed-meshheading:15361869-Antigens, CD79,
pubmed-meshheading:15361869-B-Cell-Specific Activator Protein,
pubmed-meshheading:15361869-B-Lymphocytes,
pubmed-meshheading:15361869-Chromatin,
pubmed-meshheading:15361869-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:15361869-DNA-Binding Proteins,
pubmed-meshheading:15361869-Dealkylation,
pubmed-meshheading:15361869-Mice,
pubmed-meshheading:15361869-Mice, Inbred C57BL,
pubmed-meshheading:15361869-Promoter Regions, Genetic,
pubmed-meshheading:15361869-Proto-Oncogene Proteins,
pubmed-meshheading:15361869-Receptors, Antigen, B-Cell,
pubmed-meshheading:15361869-Trans-Activators,
pubmed-meshheading:15361869-Transcription, Genetic,
pubmed-meshheading:15361869-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.
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pubmed:affiliation |
Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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