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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-9-13
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pubmed:abstractText |
Aldosterone is involved in cardiovascular diseases such as hypertension and heart failure by inducing sodium retention and vascular remodeling, which is characterized by fibroblast proliferation and migration in adventitia. It is well known that aldosterone stimulates vascular smooth muscle cells and fibroblasts to produce and secrete adrenomedullin (ADM), a multiple functional peptide with an important cytoprotective effect against cardiovascular damage. We examined the effect of aldosterone on ADM production and secretion and its mRNA expression in rat aortic adventitia to study the paracrine/autocrine interaction between endogenous ADM and aldosterone.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0263-6352
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1953-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15361767-Adrenomedullin,
pubmed-meshheading:15361767-Aldosterone,
pubmed-meshheading:15361767-Animals,
pubmed-meshheading:15361767-Aorta,
pubmed-meshheading:15361767-Cell Proliferation,
pubmed-meshheading:15361767-Connective Tissue,
pubmed-meshheading:15361767-Drug Interactions,
pubmed-meshheading:15361767-Enzyme Activation,
pubmed-meshheading:15361767-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:15361767-Gene Expression,
pubmed-meshheading:15361767-Male,
pubmed-meshheading:15361767-Organ Culture Techniques,
pubmed-meshheading:15361767-Peptides,
pubmed-meshheading:15361767-Protein Precursors,
pubmed-meshheading:15361767-RNA, Messenger,
pubmed-meshheading:15361767-Radioimmunoassay,
pubmed-meshheading:15361767-Rats,
pubmed-meshheading:15361767-Rats, Sprague-Dawley,
pubmed-meshheading:15361767-Thymine
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone.
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pubmed:affiliation |
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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