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pubmed-article:15359893pubmed:abstractTextHaemophilus influenzae type b (Hib) is the most frequent pathogen of bacterial meningitis in Japanese children. The prevalence of beta-lactamase-negative ampicillin-resistant (BLNAR) Hib strain has been increasing in recent years. Furthermore, antibiotic activities of cefotaxime (CTX) and ceftriaxone (CTRX) have decreased against some of those BLNAR strains. We report a case of one-year-old boy who suffered from meningitis caused by BLNAR Hib. The MICs of CTX and CTRX for the strain isolated from cerebrospinal fluid was 1.0 and 0.5 microg/ml, respectively. The patient was administered high-dose CTRX (150 mg/kg/day) and recovered completely without any sequela. The high-dose CTRX administration may be a considerable choice of the treatment of BLNAR meningitis.lld:pubmed
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pubmed-article:15359893pubmed:monthJullld:pubmed
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pubmed-article:15359893pubmed:authorpubmed-author:NakamuraAkira...lld:pubmed
pubmed-article:15359893pubmed:authorpubmed-author:KohnoYoichiYlld:pubmed
pubmed-article:15359893pubmed:authorpubmed-author:HoshinoTadash...lld:pubmed
pubmed-article:15359893pubmed:authorpubmed-author:IshiwadaNaruh...lld:pubmed
pubmed-article:15359893pubmed:authorpubmed-author:SudoFusayoFlld:pubmed
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pubmed-article:15359893pubmed:volume78lld:pubmed
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pubmed-article:15359893pubmed:pagination604-8lld:pubmed
pubmed-article:15359893pubmed:dateRevised2008-12-16lld:pubmed
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pubmed-article:15359893pubmed:year2004lld:pubmed
pubmed-article:15359893pubmed:articleTitle[Successful treatment of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis with high-dose ceftriaxone administration].lld:pubmed
pubmed-article:15359893pubmed:affiliationDivision of Infectious Diseases, Chiba Children's Hospital.lld:pubmed
pubmed-article:15359893pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15359893pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:15359893pubmed:publicationTypeCase Reportslld:pubmed