Linked Life Data

1535832

Source:http://linkedlifedata.com/resource/pubmed/id/1535832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-8-11
pubmed:abstractText
It has been suggested that at least two distinct genetic factors are involved in developing atopic diseases. One is the major histocompatibility complex which controls antigen-specific polymorphism of IgE antibody responses and the other is an unidentified factor(s) which controls isotype selection, i.e., class switching to IgE. It is conceivable that both expression of and sensitivity to lymphokines that play central roles in controlling IgE biosynthesis may be involved in the latter polymorphism. To explore this possibility, we have examined the sensitivities of several mouse strains to interleukin (IL)-4 and interferon-gamma (IFN-gamma). The results show that (1) the sensitivity to IgE-suppressive activity of IFN-gamma, but not to the IgE-enhancing activity of IL-4, is polymorphic (e.g., C57BL/6 is 8- to 16-fold more sensitive than BALB/c to IFN-gamma); (2) F1 of these two strains (CByB6F1) are BALB/c type and H-2 congenic mice of d haplotype with B6 background are C57BL/6 type, suggesting that low sensitivity is a non-H-2-linked dominant trait; (3) the polymorphism is determined at B cell levels; and (4) sensitivity to IFN-gamma is not associated with mRNA expression of IFN-gamma receptors (R) by B cells. These data collectively indicate that BALB/c mice have a non-H-2-linked gene which decreases B cell sensitivity to IFN-gamma, but the gene effect is not associated with the expression of IFN-gamma R mRNA on B cells. The possible biological significance of the non-H-2-linked gene is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
212-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
B cell sensitivity to IgE-suppressive activity of IFN-gamma is polymorphic and controlled by a non-H-2-linked gene.
pubmed:affiliation
Division of Immunology, Medical Biology Institute, La Jolla, California 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.