Linked Life Data

15357990

Source:http://linkedlifedata.com/resource/pubmed/id/15357990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2004-9-10
pubmed:abstractText
In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant analogues of cyclosporin A, modified at the various positions in the 'effector' domain, are equipotent nerve growth agents compared to cyclosporin A. Our results suggest that neurotrophic activity of cyclosporin A and its derivatives resides in the binding domain, and binding to cyclophilin and/or inhibiting rotamase activity may be a necessity for neurotrophic effects of cyclophilin ligands.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4549-51
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives.
pubmed:affiliation
Department of Research, Guilford Pharmaceuticals Inc., 6611 Tributary Street, Baltimore, MD 21224, USA.
pubmed:publicationType
Journal Article