Source:http://linkedlifedata.com/resource/pubmed/id/15357989
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
17
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pubmed:dateCreated |
2004-9-10
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pubmed:abstractText |
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4545-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15357989-Animals,
pubmed-meshheading:15357989-Benzamidines,
pubmed-meshheading:15357989-Pneumocystis carinii,
pubmed-meshheading:15357989-Pneumonia, Pneumocystis,
pubmed-meshheading:15357989-Rats,
pubmed-meshheading:15357989-Rats, Inbred BN,
pubmed-meshheading:15357989-Rats, Long-Evans
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pubmed:year |
2004
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pubmed:articleTitle |
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.
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pubmed:affiliation |
Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans 70125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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