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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
17
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|
pubmed:dateCreated |
2004-9-10
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|
pubmed:abstractText |
Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
6
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
4445-8
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|
pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15357969-Adipocytes,
pubmed-meshheading:15357969-Amino Acid Sequence,
pubmed-meshheading:15357969-Binding Sites,
pubmed-meshheading:15357969-Carrier Proteins,
pubmed-meshheading:15357969-Diabetes Mellitus, Type 2,
pubmed-meshheading:15357969-Drug Delivery Systems,
pubmed-meshheading:15357969-Fatty Acid-Binding Proteins,
pubmed-meshheading:15357969-Fatty Acids,
pubmed-meshheading:15357969-Humans,
pubmed-meshheading:15357969-Molecular Sequence Data
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, Biovitrum AB, SE-751 37 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article
|
