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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-8-11
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pubmed:abstractText |
Our study examined the effects of supernatants derived from CD8+ lymphocytes treated with high molecular weight components of Mycobacterium tuberculosis on cytokine production. Such suppressor but not control supernatants increased the production of IL-4 and IL-6 whilst suppressing IL-1 beta, TNF-alpha, IL-2 and IFN-gamma production by monocytes and lymphocytes. The effects on cytokine production were time dependent being observed as early as 4 hours with peak activity observed at 24 hours. The inhibition of IL-1 beta and TNF-alpha by monocytes appeared to be related to increases in IL-6 levels present in supernatants of non-adherent lymphocytes incubated with mycobacterial components. This was confirmed by studies demonstrating that the addition of recombinant IL-6 to cultures depressed the production of these cytokines. Furthermore the addition of monoclonal anti-IL6 to such cultures restored the production of IL-1 beta and TNF-alpha. The results suggest that mycobacterial components inhibit host cellular functions by manipulating the host's cytokine network.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0921-299X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1535780-Antigens, Bacterial,
pubmed-meshheading:1535780-Cells, Cultured,
pubmed-meshheading:1535780-Cytokines,
pubmed-meshheading:1535780-Depression, Chemical,
pubmed-meshheading:1535780-Humans,
pubmed-meshheading:1535780-Interleukin-4,
pubmed-meshheading:1535780-Interleukin-6,
pubmed-meshheading:1535780-Leukocytes, Mononuclear,
pubmed-meshheading:1535780-Mycobacterium tuberculosis,
pubmed-meshheading:1535780-Recombinant Proteins,
pubmed-meshheading:1535780-T-Lymphocytes, Regulatory
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pubmed:year |
1992
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pubmed:articleTitle |
Supernatants derived from CD8+ lymphocytes activated by mycobacterial fractions inhibit cytokine production. The role of interleukin-6.
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pubmed:affiliation |
Department of Immunology, School of Pathology, University of Witwatersrand, Johannesburg, Republic of South Africa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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