| pubmed-article:15356345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C0085536 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C1325410 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C1419121 | lld:lifeskim |
| pubmed-article:15356345 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:15356345 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:15356345 | pubmed:dateCreated | 2004-9-22 | lld:pubmed |
| pubmed-article:15356345 | pubmed:abstractText | Previous study in our laboratory demonstrated suppression of the gene for protein tyrosine phosphatase receptor-type O (PTPRO) in primary and established rat hepatomas. The present study showed methylation-mediated silencing of this gene in primary human lung tumors and in several human lung cancer cell lines, one of the characteristics of many tumor-suppressor genes. The reduced expression of PTPRO in the primary lung tumors correlated with the methylation status of its CpG island. Demethylation of the gene by deoxy-5-azacytidine treatment led to its reactivation in a lung cancer line (A549). Overexpression of PTPRO in A549 cells inhibited anchorage-independent growth, delayed reentry of the cells into the cell cycle after release from cell-cycle arrest, and increased susceptibility of the cells to apoptosis. These data have demonstrated the growth-suppressor characteristics of PTPRO that are unique to a classical tumor suppressor. | lld:pubmed |
| pubmed-article:15356345 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15356345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15356345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15356345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15356345 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15356345 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:TsuruoTakashi... | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:GhoshalKalpan... | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:BaiShoumeiS | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:JacobSamson... | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:SeimiyaHiroyu... | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:SusterSaulS | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:MorrisonCarlC | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:MotiwalaTasne... | lld:pubmed |
| pubmed-article:15356345 | pubmed:author | pubmed-author:KutayHubanH | lld:pubmed |
| pubmed-article:15356345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15356345 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15356345 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15356345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15356345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15356345 | pubmed:pagination | 13844-9 | lld:pubmed |
| pubmed-article:15356345 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:meshHeading | pubmed-meshheading:15356345... | lld:pubmed |
| pubmed-article:15356345 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15356345 | pubmed:articleTitle | Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. | lld:pubmed |
| pubmed-article:15356345 | pubmed:affiliation | Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA. | lld:pubmed |
| pubmed-article:15356345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15356345 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:5800 | entrezgene:pubmed | pubmed-article:15356345 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15356345 | lld:entrezgene |
| lhgdn:association:25714 | lhgdn:found_in | pubmed-article:15356345 | lld:lhgdn |
| lhgdn:association:25716 | lhgdn:found_in | pubmed-article:15356345 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15356345 | lld:pubmed |
