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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
38
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pubmed:dateCreated |
2004-9-22
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pubmed:abstractText |
Previous study in our laboratory demonstrated suppression of the gene for protein tyrosine phosphatase receptor-type O (PTPRO) in primary and established rat hepatomas. The present study showed methylation-mediated silencing of this gene in primary human lung tumors and in several human lung cancer cell lines, one of the characteristics of many tumor-suppressor genes. The reduced expression of PTPRO in the primary lung tumors correlated with the methylation status of its CpG island. Demethylation of the gene by deoxy-5-azacytidine treatment led to its reactivation in a lung cancer line (A549). Overexpression of PTPRO in A549 cells inhibited anchorage-independent growth, delayed reentry of the cells into the cell cycle after release from cell-cycle arrest, and increased susceptibility of the cells to apoptosis. These data have demonstrated the growth-suppressor characteristics of PTPRO that are unique to a classical tumor suppressor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-10497224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-10498613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-10597227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-10617649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-10792603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11027578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11152479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11238916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11248552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11470605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11584062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-11781344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-12417732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-12475979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-12606951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-12726777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-12949066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-14508512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-14627790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-14718383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-15116090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7519601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7579355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7665166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7753550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7795247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-7949101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-8631006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-8910789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-9032477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-9069265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-9403867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15356345-9694875
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13844-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15356345-Base Sequence,
pubmed-meshheading:15356345-Cell Line, Tumor,
pubmed-meshheading:15356345-DNA Primers,
pubmed-meshheading:15356345-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15356345-Gene Silencing,
pubmed-meshheading:15356345-Genes, Tumor Suppressor,
pubmed-meshheading:15356345-Genetic Vectors,
pubmed-meshheading:15356345-Humans,
pubmed-meshheading:15356345-Lung Neoplasms,
pubmed-meshheading:15356345-Protein Tyrosine Phosphatases,
pubmed-meshheading:15356345-Receptor-Like Protein Tyrosine Phosphatases, Class 2,
pubmed-meshheading:15356345-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
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pubmed:affiliation |
Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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