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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
17
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pubmed:dateCreated |
2004-9-9
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pubmed:abstractText |
Malignant rhabdoid tumor (MRT) is a rare and highly aggressive neoplasm of young children. Current treatments have had only limited success. Epidermal growth factor receptor (EGFR) was found recently to be expressed on MRT cell lines. Gefitinib (trade name Iressa) is an oral and selective EGFR-tyrosine kinase inhibitor and has been demonstrated to be effective in inhibiting the proliferation of cancer cells in vivo as well as in clinical trials. This encouraged us to examine the antitumor effects of gefitinib on MRT cells in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5940-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15355927-Animals,
pubmed-meshheading:15355927-Antineoplastic Agents,
pubmed-meshheading:15355927-Apoptosis,
pubmed-meshheading:15355927-Cell Division,
pubmed-meshheading:15355927-Female,
pubmed-meshheading:15355927-Fluorescent Antibody Technique,
pubmed-meshheading:15355927-Humans,
pubmed-meshheading:15355927-Immunoblotting,
pubmed-meshheading:15355927-Immunoenzyme Techniques,
pubmed-meshheading:15355927-Infant,
pubmed-meshheading:15355927-Mice,
pubmed-meshheading:15355927-Mice, Inbred BALB C,
pubmed-meshheading:15355927-Mice, Nude,
pubmed-meshheading:15355927-Phosphorylation,
pubmed-meshheading:15355927-Quinazolines,
pubmed-meshheading:15355927-Receptor, Epidermal Growth Factor,
pubmed-meshheading:15355927-Rhabdoid Tumor,
pubmed-meshheading:15355927-Transplantation, Heterologous,
pubmed-meshheading:15355927-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Antitumor activity of gefitinib in malignant rhabdoid tumor cells in vitro and in vivo.
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pubmed:affiliation |
Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo-ku, Kyoto 602-8566, Japan. kuwahara@koto.kpu-m.ac.jp
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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