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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2004-9-9
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pubmed:abstractText |
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome of familial malignancies. Colorectal and endometrial cancers are most frequently observed. The syndrome results mainly from germ-line mutations in DNA mismatch repair genes. A common G-to-C polymorphism at codon 72 in the p53 gene has been associated with increased risk for lung, nasopharyngeal, oral, prostate, and breast cancers and may be a marker for genetic susceptibility to colorectal cancer. We studied the influence of this p53 polymorphism on HNPCC age of onset.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5845-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15355915-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:15355915-Adult,
pubmed-meshheading:15355915-Age of Onset,
pubmed-meshheading:15355915-Aged,
pubmed-meshheading:15355915-Aged, 80 and over,
pubmed-meshheading:15355915-Carrier Proteins,
pubmed-meshheading:15355915-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:15355915-DNA, Neoplasm,
pubmed-meshheading:15355915-DNA Mutational Analysis,
pubmed-meshheading:15355915-DNA Repair,
pubmed-meshheading:15355915-DNA-Binding Proteins,
pubmed-meshheading:15355915-European Continental Ancestry Group,
pubmed-meshheading:15355915-Female,
pubmed-meshheading:15355915-Genes, p53,
pubmed-meshheading:15355915-Genetics, Population,
pubmed-meshheading:15355915-Genotype,
pubmed-meshheading:15355915-Humans,
pubmed-meshheading:15355915-Male,
pubmed-meshheading:15355915-Middle Aged,
pubmed-meshheading:15355915-MutS Homolog 2 Protein,
pubmed-meshheading:15355915-Mutation,
pubmed-meshheading:15355915-Neoplasm Proteins,
pubmed-meshheading:15355915-Nuclear Proteins,
pubmed-meshheading:15355915-Polymerase Chain Reaction,
pubmed-meshheading:15355915-Polymorphism, Genetic,
pubmed-meshheading:15355915-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:15355915-Proto-Oncogene Proteins,
pubmed-meshheading:15355915-Risk Factors
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pubmed:year |
2004
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pubmed:articleTitle |
p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population.
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pubmed:affiliation |
Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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