Linked Life Data

15355594

Source:http://linkedlifedata.com/resource/pubmed/id/15355594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-9-9
pubmed:abstractText
Mammalian cells coordinately regulate their gene expression programmes to ensure appropriate responses to stimuli. While transcriptional events provide an important level of gene expression regulation, modulation of messenger RNA (mRNA) decay provides an additional critical regulatory step. Much of the current knowledge of regulated mRNA decay comes from investigations of cytokine and other early response genes involved in inflammation and immunity. Recent genome-wide measurements of mRNA decay rates have revealed that a much broader repertoire of cellular transcripts are regulated at the level of mRNA decay, suggesting that mRNA decay plays a major role in regulating cellular function. Coupled with recent advances in understanding how signalling pathways impact on mRNA turnover, the regulation of mRNA decay emerges as an important post-transcriptional mechanism for rapidly regulating gene expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1473-9550
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-24
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Microarray-based analyses of mRNA decay in the regulation of mammalian gene expression.
pubmed:affiliation
Department of Microbiology, University of Minnesota, 420 Delaware Street, SE, MMC 196, Minneapolis, MN 55455, USA.
pubmed:publicationType
Journal Article, Review